{"references": ["1. Kardam P, Rehani S, Mehendiratta M, Sahay K, Mathias Y, Sharma R. Journey of leukoplakia so far - an insight on shortcomings of definitions and classifications. J Dent Oral Disord Ther. 2015; 3(2):1-6", "2. Lingen MW. Head and neck. In: Kumar V, Abbas AK, Aster, JC. editors. Robbins and cotran-pathologic basis of disease. 9th ed. Philadelphia: Elsevier; 2015. p. 731", "3. Barnes L, Eveson JW, Reichart P, Sidransky D (Eds): World Health Organization Classification of Tumors. Pathology and Genetics of Head and Neck Tumours. IARC Press. Lyon 2005.", "4. Scully C. Oral Leukoplakia. [eMedicine web site]. October 2008. Accessed October 30, 2009.", "5. Pindborg J.J., Reichart P., Smith C.J., and Van der Waal I. World Health Organization: histological typing of cancer and precancer of the oral mucosa. Berlin: Springer-Verlag; 1997.", "6. Eversole LR. Dysplasia of the Upper Aerodigestive Tract Squamous Epithelium. Head and Neck Pathol. 2009; 3:63\u20138.", "7. Reibel J. Prognosis of oral premalignant lesions: significance of clinical, histopathological, and molecular biological characteristics. Critical Reviews in Oral Biology and Medicine 2003; 14(1):47\u201362.", "8. Sccuba J.J. Oral leukoplakia. Critical Rev Oral Biol Med 1995;(2):147-160.", "9. Lodi G. and Porter S. Management of potentially malignant disorders: evidence and critique. Journal of Oral Pathology and Medicine 2008; 37(2), 63\u201369.", "10. Martorell-Calatayud,a R. Botella- Estrada,a J.V. Bag\u00e1n-Sebasti\u00e1n,b O. Sanmart\u00edn-Jim\u00e9nez,a and Guill\u00e9n- Baronaa C. Oral Leukoplakia: Clinical, Histopathologic, and Molecular Features and Therapeutic Approach. Acta Dermosifiliogr. 2009; 100:669-84.", "11. Sccuba J.J. Oral leukoplakia. Critical Rev Oral Biol Med 1995;(2):147-160."]}

Potentially malignant conditions precede malignancies. Oral squamous cell carcinoma has several antecedents, including leukoplakia. One of the leukoplakia varieties that usually develop into cancer is speckled leukoplakia. A significant diagnostic and therapeutic difficulty is posed by speckled leukoplakia. We have described a case of speckled leukoplakia on the right side of the buccal mucosa that developed into cancer in situ along with a review of the literature in light of recent findings. We also made an effort to discuss the clinical significance and treatment options available for the condition.