In the various industry application research on the multivariable process in nature. Control and interaction problem are major issues in the MIMO process. In the MIMO has a problem to develop a new controller very um manageable because of the interaction and process dynamics with a change of process parameters. For a simulation of the recommended method using nonlinear System. Quadruple Tank System is highly complex nonlinear systems which utilized in minimizing interaction and try to control and make stabilized the nonlinear system. The objective of the research work to design the optimized the performance index based PSO and GA implemented in Quadruple Tank System. The proposed system testing and simulation in MATLAB recourses. In this technique gives better disturbance attenuation with the good performance index result.