Synthesis And Analgesic Activity Of 3-Amino-6-Bromo-2-Methyl Quinazolin-4(3H) –One And 6-Bromo-2-Methyl-4H-Benzo[D] [1,3]- Oxazin-4-One

The current study is aimed at the synthesis and Analgesic evaluation of quinazolinone derivatives. The condensation of Methyl-2-amino-5-bromobenzoate with acetic anhydride yielded the cyclic compound 2-methyl 6-bromo-1, 3-benzo-oxazine-4-one which further produce 3-Amino-2-Methyl 6-bromoquinazolin4(3H)-ones via the reaction with hydrazine hydrate. The compounds synthesized were unequivocally confirmed by means of Chromatography Mass Spectrophotometer and Elemental analysis. The quinazolonones were evaluated pharmacologically for their in-vivo analgesic activities by acetic acid induced writhing in mice. The two investigated compounds exhibited significant analgesic activity in the range of 74.67 - 83.80% in compared to control.

Related Organizations

Ondo State University of Science and Technology
Nigeria

Keywords

Analgesic, 3-amino-6-bromo-2-methyl quinazolin-4(3H)-one, 6-bromo-2-methyl-4H-benzo [d] [1,3]-oxazine-4-one, Nucleophile, Quinazoline-4(3H)one

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