This review research article has gone through the cancer incidence in domesticated and wild animals. Cancer causes approximately 50 percent of deaths in pets over the age of 10. Some common types of cancers in pets include are skin, breast, head and neck, lymphoma, leukemia, testicular, abdominal, and bone. Cancers commonly found in pets that are also commonly found in humans are lymphoma, melanoma, and osteosarcoma. The two most common household pets, dogs tend to get cancer at a higher rate than cats. The cancer may be treatable depending on cancer type and the treatment options for dogs and cats are similar to those for humans. The cancer incidence in wild animals is much less than domesticated animals which are due to their lifestyle and nutrition type. The reason behind the cancer incidence in wild animals is the environmental parasites, viruses, bacteria and fungi. It seems the traditional lifestyle and nutrition is very important in the prevention of the cancer in humans as well.