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Presentation . 2017
License: CC BY
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ZENODO
Presentation . 2017
License: CC BY
Data sources: Datacite
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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Other literature type . 2017
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Sgc-Aak1-1: A Chemical Probe Candidate For The Understudied Kinases Aak1 And Bike/Bmp2K

descriptionPublicationkeyboard_double_arrow_right Presentation , Other literature type 28 Aug 2017Publisher:ZenodoFunded by:WT | unidentified
Authors: Axtman, Alison D.; Azeez, Kamal Abdul; Bennett, James M.; Couñago, Rafael; Drewry, David H.; Elkins, Jonathan M.; Fedorov, Oleg; +13 Authors

doi: 10.5281/zenodo.852630 , 10.5281/zenodo.852631

Sgc-Aak1-1: A Chemical Probe Candidate For The Understudied Kinases Aak1 And Bike/Bmp2K

Abstract

SGC-AAK1-1 is presented as a chemical probe for the understudied kinases (adaptor protein 2)-associated kinase (AAK1) and (bone morphogenetic protein 2)-inducible kinase (BIKE/BMP2K). SGC-AAK1-1 is potent with submicromolar cellular target engagement with AAK1. The compound shows > 30-fold selectivity in binding relative to all other kinases profiled with the exception of RIOK1, RIOK3, and PIP5K1C. A closely related molecule that is significantly less potent with AAK1 and BIKE/BMP2K, SGC-AAK1-1N, is included as a negative control.

The SGC is a registered charity (number 1097737) that receives funds from AbbVie, Bayer Pharma AG, Boehringer Ingelheim, Canada Foundation for Innovation, Eshelman Institute for Innovation, Genome Canada, Innovative Medicines Initiative (EU/EFPIA), Janssen, Merck & Co., Novartis Pharma AG, Ontario Ministry of Economic Development and Innovation, Pfizer, São Paulo Research Foundation-FAPESP, Takeda, and Wellcome Trust.

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Keywords

Kinase chemical probe, BIKE/BMP2K, AAK1

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selected citations
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This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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