The present investigation was focused with much attention to investigate the pharmacological activity of Cissus quadrangularis plant extract mediated silver nanoparticles. Anti-inflammation activity of the silver nanoparticles of the plant Cissus quadrangularis in mice model was studied using formalin induced paw oedema method. The anti-obesity effect of nanoparticle synthesized plant extract Cissus quadrangularis with fat rich diet of egg feed induced in albino mice was also assessed. Nanoparticles were also studied for its immune response against SRBC with hydrocortisone induced mice model. The oral administration of plant extract (100mg/kg) exhibited increased the percentage of inhibition paw oedema with 50% at 4 hours while the standard drug paracetamol (100mg/kg) revealed a less percentage of inhibition paw oedema with 37.5% after 4 hours. It was found out that, the amount of SGOT and SGPT enzymes present in the serum of Hydrocortisone treated mice revealed 184U/ml and 149 U/ml. The results of hypolipidemic effect revealed that, the nanoparaticle alone significantly reduced the total cholesterol to 128 ± 4.1 mg/dl rather compared to other groups. The nanoparticles obtained from Cissus quadrangularis exhibited significant anti-inflammatory, immunomodulatory and hypolipidemic activities without any serious side effects