In this article first we try to understand the responsibilities dealt by clinical pharmacist and the role computers are playing in enhancing clinical pharmacy profession. Clinical pharmacists serving as reliable scientific information resource are trained & experienced professionals in patient care & medication management. They collect huge data for fulfilling various tasks such as drug optimization, information building on usage of medication & disease prevention and also maintaining health outcomes of patient’s. With such a huge task requiring computers has become part of their profession & practice. In detail we discuss how advantageous proven on utilization of computers along with their area of applications. Keywords: clinical pharmacy, computers, patient care, medication management.