Flexible electronics have gained popularity because of their capability to combine softness and functionality. Soft resistive sensors are susceptible to mechanical stimuli and detecting temperature selectively remains a challenge. In this study, soft flexible thermistors are developed for detecting temperature changes based on the positive temperature coefficient (PTC) effect, selectively. By thermomechanical analysis and differential scanning calorimetry, it is observed that thermoplastic elastomers with higher thermal expansion and semicrystalline morphology result in a sensitive thermistor response. To achieve a high sensitivity in temperature and low sensitivity in the detection of mechanical stimulus, a low-carbon filler content is required. The opposite trend is seen for the piezoresistive sensors for mechanical strain detection. Both sensory material types are compatible with thermoplastic material extrusion-based additive manufacturing. The method is used for the fabrication of the sensing elements and an open-source prosthetic hand. The strain sensor detects the bending of the fingers and the temperature sensor detects the temperature when in contact with a heated surface, successfully. In addition, the temperature sensor is used as a tactile sensor to detect contact with a non-heated surface. Combining selective multisensory capabilities will significantly affect the future development of sensorized prosthetic devices and wearable electronics.