In a recently published article, Daley et al. (2023) emphasized the need for a new approach to assess cardiotoxicity of environmental compounds, an issue that has been neglected to date. They described how efforts for the evaluation of cardiotoxicity have so far focused on pharmaceuticals and the necessity of new approach methodologies (NAMs) that do not directly rely on animals beyond the pharmaco-regulatory sector. Here, we aim to add to that paper by providing information on the specific limitations of the current regulations for a) chemicals, biocides, and pesticides, b) human variability including the elderly population, and c) chemical mixtures. We also briefly indicate how each of these specific limitations could be overcome using NAMs.