Objective: This study was conducted to determine the relationship between the perceptions of nursing care and anxiety and depression in inpatients diagnosed with COVID-19. Methods: 236 patients hospitalized with COVID-19 in a public hospital between 1 March 2022 and 25 April 2022 constituted the sample of the cross-sectional correlational study. "Patient Description Form", "Hospital Anxiety and Depression (HAD) Scale" and “Scale of Patient Perception of Hospital Experience with Nursing Care (PPHEN)” were used as data collection tools. Numbers and percentage calculations, arithmetic mean, median (25th-75th percentile), Mann Whitney U test, Kruskal Wallis, and Linear Regression analysis were used to analyze the data. Results: The mean HAD-Anxiety score of the patients was 9.79±6.40, the mean HAD-Depression score was 8.45±6.73, and the mean score of the PPHEN was 54.20±18.22. There was a strong and significant negative correlation between the HAD-Depression and HAD- Anxiety mean scores of the patients and the mean score of PPHEN. By the results of multiple linear regression analysis, it was determined that the factors significantly influencing the patients' perception of nursing care were depression and anxiety states, the length of hospital stay, the severity of COVID-19 symptoms, and getting information from nurses. Conclusion: It was found that the anxiety and depression levels of the patients were mild, and the perception of nursing care was high. It was determined that patients' high perceptions of nursing care positively affected their low anxiety and depression levels.