A unique drug delivery system is an innovative approach to medication delivery that solves the shortcomings of standard drug delivery systems. Our country has a vast Ayurvedic knowledge base whose potential has just recently been exploited. If innovative drug delivery technology is used in herbal medicine, it may improve the efficacy and reduce the negative effects of diverse herbal compounds and herbs. Due to a lack of scientific explanation and processing problems, such as standardisation, extraction, and identification of specific medication components in complex polyhedral systems, development as innovative formulations. This review will provide a thorough understanding of the various types of bioactive chemicals, as well as those specifically involved in skin and topical application, novel methods to TDDS, specifics of transferosome, comparison of phytososme, liposome, and transferosome, and widespread application of transferosme. Keywords: Phytochemicals, Bioactive compounds, Novel drug delivery systems, Transferosome,