Betalains are a group of water-soluble pigments found in certain plants, particularly in the order Caryophyllales, which includes beets, cactus, and amaranth. They are responsible for the bright red-violet and yellow-orange colors of these plants. Betalains are divided into two groups: betacyanin’s, which are the red-violet pigments, and betaxanthins, which are the yellow-orange pigments. These pigments are distinct from other plant pigments such as anthocyanins and carotenoids. Betalains have been found to have potential health benefits, such as anti-inflammatory and antioxidant properties. They have also been studied for their potential as natural food colorants and in the treatment of certain diseases. However, Betalains are not found in all plants, and they are relatively rare compared to other pigments. Their biosynthesis and regulation in plants are still not fully understood, and further research is needed to fully understand their potential benefits and uses. This review covers research results and demonstrates the therapeutic potential of Betalains across a range of disorders.