Background: Non psychiatric nurses care for hospital patients with behavioral health conditions.. Objectives: The current study aimed to assess practice towards Psychiatric, Patients with Aggressive Behaviors at Khartoum Psychiatric Hospitals. Materials and methods: Descriptive cross sectional hospital based design was used to conduct this study at a Psychiatric Hospital in Khartoum. The target population consisted of 60 nurses employed at the Khartoum Psychiatric Hospital. Structured questionnaires were distributed to the participants for data collection. Data analysis was done using a Statistical Package for Social Science, version 24, and nominal as well as ordinal data was analyzed using descriptive analysis. The study showed that the overall practice of nurses towards psychiatric patients with an aggressive behavior was found good among 71.5% and poor among 28.5%. There was association between overall practice of nurses towards psychiatric patients with an aggressive behavior and age group<0.05. Nurses has overall adequate practice towards psychiatric patients with an aggressive behavior. While the age was significantly influence the practice of nurse towards psychiatric patients with an aggressive behavior. Future studies with large sample size will be recommends.