The article evaluates the diagnostic possibilities of determining the level of NETs in the effectiveness of the treatment of chronic tonsillitis. A comparative study of neutrophils and netosis-transformed leukocytes was carried out in 120 patients diagnosed with chronic tonsillitis. %NETs were determined in blood smears of the "monolayer" type and smears from the surface of the palatine tonsil lacunae, which were then stained according to Romanovsky-Giemsa. Smear microscopy was performed using the MEKOS-C2 automated system. A comparative analysis of the number of identified NETs in groups showed that in patients with chronic tonsillitis, %NETs are 2 times higher than in healthy donors. Assessment of %NETs after the treatment showed that in the third group there was a decrease in this indicator in the blood by 40.5%, and in smears from the surface of the lacunae of the palatine tonsils by 33.3%. Thus, the combination of NM lacunae lavage and local NO-therapy procedures is the most effective way to influence the tissue focus of inflammation.