Corona outbreak opens lots of scientific correlations of COVID virus with other similar virus. As it is highly mutating and contagious virus critical analysis and comparative studies are one of the most important tasks for identification of characteristic of this virus. Comparisons and co relations between the COVID-19 virus and influenza can be possible at different microscopic level. As COVID-19 outbreak continues to emerge and evolve, comparisons drawn as both cause respiratory disease, yet both have significant differences between them and how they spread. Computational examination is important and done by utilizing KEGG database for the influenza virus and tracing the equivalent for SARS-CoV-2, and furthermore by tabulating the biochemical, cellular and pathway contrasts between the two. It has important implications for public health measures and bioinformatics studies as the highly infective Coronavirus Disease-19 (COVID-19) is caused by a novel strain of Coronaviruses the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). This study becomes more imperative from the viewpoint to take all the necessary precautions and measures both on extrinsic front as public health and hygiene by following sanity measures as well as by following natural diet methods and plant based products which acts as immunity booster and all this will be possible only when we know the Scientific background for the same. Therefore, it is also important to generate awareness also.