This upload provides Open Data associated with the publication "Prognostic value of the De Ritis ratio for overall survival in patients with metastatic castration-resistant prostate cancer undergoing [177Lu]Lu-PSMA-617 radioligand therapy" by Gaal S et al. (2023). The upload contains the anonymized dataset of 91 patients analyzed in this publication with all variables that are required to reproduce the results. However, to fully comply with requirements for data anonymization, the patients' age was categorized into groups spanning 5 years each. A dataset with the age variable in exact years can be obtained from the corresponding author (julian.rogasch@charite.de) upon reasonable request. Besides the dataset, this upload provides a dictionary to explain all variables and their categories.