This dataset contains all the raw mass cytometry (CyTOF) and flow cytometry fcs files associated with Capelle et al. 'Early-to-mid stage idiopathic Parkinson's disease shows enhanced cytotoxicity and differentiation in CD8 T-cells in females', Nature Communications, 2023, In Press. The dataset contains the following information: 1, The folder " CoPImmunoPD Flow Zenodo V2.zip " contains all the raw fcs files of flow cytometry analysis and the excel table with marker information of five staining panels in the initial discovery analysis using fresh blood samples. The folder also includes the fcs files of analyzing cytotoxicity potential within CD8 T cells and of validation analyses using cryopreserved samples. Single-color/fluorochrome staining files have also been provided for the relevant experiments in the given subfolders for compensation. 2, The folder "CoPImmunoPD_CyTOF_Zenodo.zip" contains all the raw fcs files generated from the CyTOF measurements in the initial discovery analysis. To reproduce our published Figures, please be assure to first read all the accompanied readme/excel information annotation files deposited in the corresponding folders within the zip files, all the Source Data files of different main and supplementary Figure subpanels, Methods and/or any other relevant sections in our manuscript.