This is the accepted manuscript version of the work published in its final form as Virgilio A., Esposito V., Tassinari M., Nadai M., Richter S N., & Galeone A. (2020). Novel monomolecular derivatives of the anti-hiv-1 g-quadruplex-forming hotoda's aptamer containing inversion of polarity sites. European Journal of Medicinal Chemistry, 208 112786. https://doi.org/10.1016/j.ejmech.2020.112786 Deposited by shareyourpaper.org and openaccessbutton.org. We've taken reasonable steps to ensure this content doesn't violate copyright. However, if you think it does you can request a takedown by emailing help@openaccessbutton.org.