Abstract: Topical administration of the Tolmetin is an anti-inflammatory agent with analgesic and antipyretic properties. It is used to treat osteoarthritis, rheumatoid arthritis and control acute pain. The therapeutic effects of Tolmetin are achieved via inhibition of the synthesis of prostaglandins involved in fever, pain, swelling and inflammation. Although, topical application of Tolmetin offers the advantage of delivering a drug directly to the disease site in order to maximize local effects without concurrent systemic activity yet, no formulation of Tolmetin is available in the market for topical use. The most difficult aspect of the topical drug delivery system is the formidable barrier properties of the stratum corneum (SC), the outermost layer of the skin that prevents percutaneous absorption of drugs. Keywords: Tolmetin, Zeta potential, X-ray Diffraction Studies.