Downloads provided by UsageCountsDifferential T-cell and monocyte responses in hepatocellular carcinoma treated with regorafenib plus nivolumab: an integrated clinical and biomarker analysis of the phase 2 RENOBATE trial
Hyung-Don Kim; Seyoung Jung; Ho Yeong Lim; Baek-Yeol Ryoo; Min-Hee Ryu; Hong Jae Chon; Beodeul Kang; +9 Authors
Hyung-Don Kim; Seyoung Jung; Ho Yeong Lim; Baek-Yeol Ryoo; Min-Hee Ryu; Hong Jae Chon; Beodeul Kang; Jung Yong Hong; Han Chu Lee; Deok-Bog Moon; Ki-Hoon Kim; Tae Won Kim; Jeong Seok Lee; Richard S. Finn; June-Young Koh; Changhoon Yoo;
Differential T-cell and monocyte responses in hepatocellular carcinoma treated with regorafenib plus nivolumab: an integrated clinical and biomarker analysis of the phase 2 RENOBATE trial
Regorafenib plus nivolumab (RegoNivo) combination has shown promising anti-cancer activity in multiple cancer types. REBNOBATE trial is a single-arm multicenter phase 2 trial of first-line RegoNivo in patients (pts) with uHCC (NCT04310709). Here we report the clinical outcomes of the RENOBATE study and integrative biomarker analysis using circulating tumor DNA (ctDNA) and single cell RNA sequencing (scRNA-seq) analysis.
- University of Ulsan Korea (Republic of)
- Samsung Medical Center Korea (Republic of)
- Asan Medical Center Korea (Republic of)
- CHA University Korea (Republic of)
- University of California, Los Angeles United States
Hepatocellular carcinoma; regorafenib-nivolumab; pharmacologic biomarker; classical monocytes; proliferating CD8+ T cells; and immune evasion.
Hepatocellular carcinoma; regorafenib-nivolumab; pharmacologic biomarker; classical monocytes; proliferating CD8+ T cells; and immune evasion.
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This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Influence provided by BIP!impulseImpulse provided by BIP!
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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