Background: Coronary artery disease is one of the most prominent forms of cardiovascular illness, which is a condition that affects people from all over the world. It has been proven beyond a shadow of a doubt that this disease is the primary reason for death in both industrialized nations and undeveloped nations (Yousefi, Rezaei and Hoseini, 2015). Objectives: To assess pain severity scores and vital signs before interventional program for patients undergoing arterial sheath removal after coronary angioplasty. To determine the effect of the interventional program on severity of pain through measuring vital signs and pain severity scores for patients undergoing arterial Sheath Removal after coronary angioplasty. Methodology: A quasi-experimental design of the study has been used in the present study to assess reduction of pain intensity for patients undergoing Arterial Sheath Removal after coronary artery angioplasty: an interventional program in Al Hussain Teaching Hospital during the period from January 21st, 2023 to April 13th 2023. Those patients are divided into two groups 30 patients for the study group was exposed to the interventional program and 30 patients have been assigned to the control group who are not exposed to the interventional program. Results: Descriptive analysis of studied sample pain intensity for study and control groups before and after applying the interventional program. It can be seen that mean score of pain for both study and control groups before applying interventional program have nearly the same mean score (5.50±2029 vs. 5.73±2.196) respectively. In contrast after applying interventional program the mean score of pain for study group is much lesser than control group as follows respectively (0.66±0.802 vs.5.40±1.830). Conclusion: There are highly significant differences regarding pain intensity between the study and control groups of the current study after applying the interventional program. There are highly significant differences regarding following vital signs readings between the study and control groups of the current study after applying the interventional program. Recommendations: Adopt the interventional program to be used and applied in other hospitals nationally. Train nurses to apply the program in relevant situation to achieve a benefits of the patients and to improve nursing care.