Identified changes in the immune status of children with bronchopulmonary pathology living in an unfavorable environmental environment; children with pneumonia and obstructive bronchitis had high levels of immunoglobulin Ig E and low levels of sIgA. Interleukin IL-4 in pneumonia had higher values than the reference value of 60%, in obstructive bronchitis 90%, this indicates a change in both cellular and humoral immune imbalance, which subsequently leads to more severe diseases of the bronchopulmonary system