An appropriately designed sustained or controlled release drug delivery system can be a major advance towards solving the problem associated with the existing drug delivery system. Microspheres as a novel drug delivery system for oral administration are having the feasibility of carrying the drug. These are the monolithic spheres or therapeutic agent distributed throughout the matrix as a molecular dispersion of particles. Rational behind the drug encapsulation into microspheres is preparation of suitable formulation with longer duration of action for control release thereby sustaining the role of release of core material by rupture of polymeric wall. This will also reduce the dosing frequency and helps to improve the patient compliance. The aim of present work was to produce and characterize Repaglinide (Rg) polymeric microspheres by solvent evaporation method, in an attempt to obtain a delivery system adequate for the treatment of diabetes. Batches were prepared with different ratios of drug and polymer. Polymeric microspheres of Repaglinide were successfully prepared using Eudragit RSPO as polymer by emulsion solvent evaporation method. The prepared microspheres were evaluated for percentage yield, particle size, and drug entrapment efficiency, scanning electron microscopy, micromeritic studies and in vitro drug release study. From all the evaluation parameters the batch which is considered to be optimized batch, the final formulation i.e. tablet were prepared from the microspheres prepared in that optimized batch.