Hyperbranched monodisperse macromolecules with persistent shape and constrained size are called dendrimers. Topological indices are numerical parameters that relate the molecular structure's chemical, physical, and biological characteristics. We calculated the novel R, S, and Van molecular topological indices of polyphenylene dendrimer, which are degree-based molecular descriptors. Our findings contribute to a deeper comprehension of the characteristics of polyphenylene dendrimer that can be employed in medication development