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The buccal region of the oral cavity is an alternative target for the delivery of the medicine of choice in order to overcome the limitation associated with the other route of administration. The significant pre systemic metabolism, instability in acidic medium, and insufficient absorption of the medications are the drawbacks of oral drug delivery. The transmucosal method offers the advantages of being simple to administer, patient-acceptable, and affordable. Buccal transmucosal administration, which provides immediate access to the systemic circulation via the internal jugular vein, aids in avoiding first-pass metabolism. The review article's objective is to provide a mechanism of bioadhesion, general overview of buccal drug delivery, oral mucosa anatomy, drug penetration mechanisms, and their in-vitro and in-vivo mucoadhesion testing methods and evaluation parameters of tablet of buccal drug delivery system.