ABSTRACT. The geochemical associations and spatial distribution of chemical elements in the Sedefche deposit are studied. The ore deposit is located in the easternmost part of the Zvezdel-Pcheloyad ore field. The data obtained during the exploration drilling program conducted in the period 2019-2020 by Gorubso-Kardzhali JSC was used to determine the spatial correlation between the chemical elements and their geochemical associations. A total of 28 elements were included for the statistical data processing. The results of the factor analysis reveal that the total variation is decomposed on 7 factor axes. The results of the 3D modelling of the factor scores contributes to clarify the geochemical associations and spatial distribution of groups of elements characterised by a certain similarity. The association of ([Ag, Pb, Sb, Au] Cu, As, Cd) from factor 2 represents the distribution of the main ore elements in the deposit. The other associations that follow the morphology of the ore bodies are represented by factor 1 ([Mn, Be, Co, Zn, Fe] Al, Ni, Tl) and factor 3 ([Hg, Tl, Mo, As] S, Au, K, Sb) and probably describe the distribution of the Quartz-sphalerite-galena, the Quartz-arsenopyrite, and the Sulfosalt parageneses.