Oral cancer is one of the common cancers in the worldwide, with a delayed clinical detection and prognosis. There is no specific biomarkers for this kind of disease and also no expensive therapeutic alternative methods. It is two to three times more prevalent in men than women in most ethnic groups. It is a preventable disease, where smoking and alcohol-considered major risk factors. India has one of the highest incidences of oral cancer and delayed stage recovery is common. Surgery remains the treatment of choice and adjuvant treatment is recommended in patients with high-risk. Functional outcomes and treatment-related morbidity needs to be considered, and reconstruction with free tissue transfer provides the best outcomes. Particularly while speech, swallowing, mastication efficiency, and dental rehabilitation. Future generations has to fight these dreadful diseases until scientists and clinicians are provided the opportunities to expand efforts to prevent, detect (early), and eradicate oral and other head and neck cancers.