Cempedak (Artocarpus integer (Thunb.) Merr.) is a plant with the genus Artocarpus that grows in Kalimantan and has properties as antimalarial, antidiabetic, abdominal pain and anticancer. This study aims to determine the specific and non-specific parameters of simplisia. The method used refers to the Indonesian Herbal Pharmacopoeia and General Standard Parameters of Extracts. Samples came from the South Kalimantan Province and Central Kalimantan Province. The results of the organoleptic test of simplisia are in the form of powder, light green in color, smelling typical of leaves and tasteless. Microscopic results show epidermis, sclerenchyma, xylem, phloem, air cavities, chlorophyll and stomata. The results of each test have a range, namely ethanol soluble juice content 17.80% - 25.40%, water soluble juice content 15.27% - 19.33%, total ash content 8.07% - 10.25%, acid insoluble ash content 2.32% - 3.82%, Pb metal contamination <0.001 - 0.004 mg/kg and Cd 0.160 - 0.178 mg/kg. A. integer leaf simplisia contains alkaloid, flavonoid, saponin, tannin, glycoside, phenolic and anthraquinone compounds which are confirmed on the KLT profile with the same compound content. Total phenol content was 18.88% - 20.29% b/w EAG. The test results of specific and non-specific parameters of A. integer leaf simplisia from two different places have met the requirements set by the Indonesian Herbal Pharmacopoeia and BPOM RI.