Supplementary datasets for the study titled: 'Multiple Introductions of Mpox virus to Ireland during the 2022 International Outbreak' The datasets presented here are the list of publicly available sequences from other locations used as reference for analysis of our sequences (Supplementary Table 1), the list of sequenced mpox viruses (MPXV) in the Republic of Ireland (Supplementary Table 2) and the list of MPXV genes with mutations in our dataset of Irish sequences (Supplementary Table 4). Description of the data and file structure The files in this dataset were formatted in Microsoft Excel 2019 to allow easy access and manipulation of the data. The data corresponds to details on the sequences used in the analysis of the MPXV from the 2022 international outbreak encompassing data between May and November of 2022. The contents of the files are described below: -Supplementary Table 1: This file contains the source (database as GenBank or GISAID) of the data, the accession number to allow its downloading, the assigned mpox clade, reported collection date of the sample, reported country of origin and the geographical region assigned. -Supplementary Table 2: This file contains details on the sequences generated in our study with the GenBank accession number, the GISAID accession number, reported collection date, GISAID assigned taxonomical clade and the percentage of the genome covered by the sequence. -(Supplementary Table 3): This table was omitted as it is small and summarizes the counts of mutations. -Supplementary Table 4: This file contains a distribution of mutated positions over the annotated MPXV genome relative to the reference ON676708, with gene affected, start and end of the gene (relative to the reference genome GenBank:ON676708), number of non-coding, non-synonymous and synonymous mutations in each gene, and the total of mutations per gene. Sharing/Access information The databases used to extract and deposit the data were: -GenBank: the North American repository of sequences and publicly available at: https://www.ncbi.nlm.nih.gov/genbank/ -GISAID: International consortium of sequences with some metadata and clinical data. It is a semi-public repository with easy access requiring only to create an account. Available at: https://gisaid.org/