The mouth-dissolving tablets for the anti-emetic drug in the current investigation were made utilizing the direct compression method using both natural and synthetic super disintegrants. Sodium starch glycolate (2–8%) and ocimum basilicum seed mucilage (2–8%) were utilized as synthetic and natural super disintegrants, respectively, in the direct compression method. By extracting the drug with 0.1 N HCl and pH 6.8 phosphate buffer and measuring the absorbance at 254 nm, the anti-epileptic drug content in the prepared tablet formulations was determined. The prepared formulations were further tested for post compression paremeters. In vitro drug release pattern (0.1 N HCl and pH 6.8 phosphate buffer),stability study (at 40ºC/ 75% RH for 6 months),drug-excipient interaction (IR spectroscopy) in vitro dispersion time respectively in comparison with formulations containing natural super disintigrant. The promising formulations containing 8% w/w Synthetic super disintigrant Sodium starch glycolate emerged as the overall best formulation formulations (FCZ4). Short-term stability studies of promising formulations indicated that there are no significant changes in drug content and in vitro dispersion time (p<0.05).IR-spectroscopic studies indicated that there are no drug-excipient interactions. It can be concluded from the present work that synthetic super disintigrant were found to be superior in compression with natural super disintegrante with improved dissolution. Keywords: Clonazepam, Ocimum basilicum seed mucilage,Sodium starch glycolate etc.