Abstract Objective: To evaluate clinic pathological correlation of Leiomyomas undergoing myomectomy in tertiary care hospital. Methodology: This cross-sectional study was conducted at Gynaecology and Obstetrics Department, Services Institute of Medical Sciences Lahore, from June2019 to September 2022 on a sample of 123 eligible patients. After a detailed history investigations and clinical examination, e.g. CBC, blood grouping, fasting blood sugar, ESR, ultrasound scan, laparotomy was performed and the size of uterus, tubal and ovaries condition and total number and location of fibroids we noted.Atubal patency test using methylene blue was performed. Histopathological examination was performed to confirm any endometrial pathology or degenerative process. The data was analysed SPSS 21.0. Categorical variables like demographic profile, clinical characteristics, and location of myoma were presented as frequency and percentages. Results: Mean age was 25.23±5.623 years. In the study population, 69.1% were nulliparous. Heavy menstrual bleeding was the commonest symptom, constituting 44.7%, mass in abdomen in 30.1%, infertility in 22% and dysmenorrhea in 3.3% cases. Most common site of leiomyoma was Intramural (51.21%), Subseroal 29.26%, and Submucous 19.51%. Conclusion: The study concluded that leiomyoma is one of the most common diseases of reproductive age.