The article presents data on the causes, threats of preterm birth and early diagnosis and prediction of the risk of developing a threat of preterm birth in women with infections of the genitourinary system. Despite numerous scientific and practical studies, the frequency of preterm birth does not decrease, and in some countries even increases, which requires further comprehensive study and improvement of diagnostic and therapeutic measures. This article presents the results of a prospective study of childbirth in pregnant women in whom childbirth was complicated by premature and prenatal rupture of amniotic fluid delivered in the Bukhara city maternity complex and the regional perinatal center for the period 2018-2022. The results obtained indicate a significant role of PPROM, PROM in the development of obstetric complications, especially in women with a burdened somatic and gynecological history.