The article presents data on the causes, GDM (Gestational Diabetes Mellitus) and early diagnosis, predicting the risk of developing GDM in obese women. Despite numerous scientific and practical studies, the frequency of GDM does not decrease, and in some countries even increases, which requires further comprehensive study and improvement of diagnostic and therapeutic measures. This article presents the results of clinical and anamnestic data and indicators of reproductive health of women with hyperglycemia in the blood. It became known that out of the analyzed data of 68 pregnant women with GDM complications, all of them were diagnosed on the basis of clinical and anamnestic (obesity, large fetus, antenatal fetal death, polyhydramnios, fetal malformation), instrumental and diagnostic data. In pregnant women in Bukhara and Navoi regions in 2017-2022. The results obtained indicate a significant role of GDM in the development of obstetric complications, especially in women with a burdened somatic, hereditary and obstetric history.