Abstract: Lung cancer remains a leading cause of cancer-related mortality, underscoring the urgent need for innovative therapeutic strategies. This study investigates the anti-cancer properties of Rhaphidophora decursiva extracts (methanol and ethanol) on lung cancer cells in vitro. The research encompassed various assays including cytotoxicity, cell viability, colony formation suppression, and flow cytometry to ascertain the extracts' efficacy. Significant inhibition of cell proliferation, colony formation, and cell cycle arrest at the G0/G1 phase were observed, highlighting the therapeutic potential of these extracts. The findings reveal Rhaphidophora decursiva as a promising natural remedy and provide a foundation for future in-depth investigations. This research represents a step towards harnessing the power of natural products in the fight against lung cancer.