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Dedifferentiated chondrosarcoma is a rare and most malignant form of chondrosarcoma, accounting for approximately 11 % of all chondrosarcomas. It generally occurs in older patients having slight male predilection. However, patient in the present case was comparatively younger female with tumour mass in Humerus . The prognosis of dedifferentiated chondrosarcoma is poor. Distant metastasis especially in lungs is often seen. This case is reported here because of its rarity, its association with worse prognosis and absence of pulmonary metastasis, however, subcutaneous nodules were seen at local site.