The present investigation of this work “To Design and Development of Liposphere Containing Chlorthalidon Suspension for Oral Delivery” were developed and leads to liposphere, present work explain the mechanism of Liposphere release from Suspension In this work particles were prepared by using Cetyl alcohol consisting of Cetostearyl alcohol Xanthum gum, which can be act as a suspending agents. Melt dispersion method based on Though number of micro encapsulation technique have been employed to produce polymeric multiparticulate system, The morphological characterization of the optimized liposphere were examined by scanning electron microscope with suitable magnification Keywords: Liposphere, Chlorthalidon, Phospholipids