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License: CC BY
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License: CC BY
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Multiple sequence-alignment-based RNA language model and its application to structural inference

Authors: Yikun Zhang; Mei Lang; Jiuhong Jiang; Zhiqiang Gao;

Multiple sequence-alignment-based RNA language model and its application to structural inference

Abstract

News: More details and updates can be found at https://github.com/yikunpku/RNA-MSM This project contains codes and pre-trained weight for MSA RNA language model (RNA-MSM) as well as RNA secondary structure and solvent accessibility tasks and corresponding RNA datasets. RNA-MSM is the first unsupervised MSA RNA language model based on aligned homologous sequences that outputs both embedding and attention map to match different types of downstream tasks. The resulting RNA-MSM model produced attention maps and embeddings that have direct correlations to RNA secondary structure and solvent accessibility without supervised training. Further supervised training led to predicted secondary structure and solvent accessibility that are significantly more accurate than current state-of-the-art techniques. Unlike many previous studies, we would like to emphasize that we were extremely careful in avoiding over training, a significant problem in applying deep learning to RNA by choosing validation and test sets structurally different from the training set. More details can be found at https://github.com/yikunpku/RNA-MSM

Keywords

Multiple sequence-alignment, RNA structure prediction, LLM

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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