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Giant cell lesions of the jaw include cherubism, central giant cell granuloma (CGCG) peripheral giant cell granuloma (PGCG) aneurysmal bone cyst, traumatic bone cyst and jaw tumour of hyperparathyroidism. The histological, radiographic and clinical diagnosis is particularly difficult in these types of lesions due to their variable clinical behavior and identical histological presentation with abundant giant cells. We present the case of a 12-year-old boy, who developed a painless swelling of approximately 4 cm, in the left angle of the mandible. The lesion demonstrated slow, progressive and continuous growth. The patient was surgically treated by a conservative approach. The histopathology confirmed the suspected diagnosis of central giant cell granuloma.