Below you'll find code and data associated with the following article: Bozzuto, C, Ives, AR (2023): Differences in COVID‐19 cyclicity and predictability among U.S. counties and states reflect the effectiveness of protective measures. Scientific Reports. https://doi.org/10.1038/s41598-023-40990-0. ABSTRACT: During the COVID‐19 pandemic, many quantitative approaches were employed to predict the course of disease spread. However, forecasting faces the challenge of inherently unpredictable spread dynamics, setting a limit to the accuracy of all models. Here, we analyze COVID‐19 data from the USA to explain variation among jurisdictions in disease spread predictability (that is, the extent to which predictions are possible), using a combination of statistical and simulation models. We show that for half the counties and states the spread rate of COVID‐19, r(t), was predictable at most 9 weeks and 8 weeks ahead, respectively, corresponding to at most 40% and 35% of an average cycle length of 23 weeks and 26 weeks. High predictability was associated with high cyclicity of r(t) and negatively associated with R0 values from the pandemic’s onset. Our statistical evidence suggests the following explanation: jurisdictions with a severe initial outbreak, and where individuals and authorities took strong and sustained protective measures against COVID‐19, successfully curbed subsequent waves of disease spread, but at the same time unintentionally decreased its predictability. Decreased predictability of disease spread should be viewed as a by‐product of positive and sustained steps that people take to protect themselves and others.