Mucoadhesive buccal patches of Clonidine were prepared using different polymers like HPMCK4M, Xanthan Gum and Guar gum in various proportion and combinations by solvent casting method.The patches were evaluated for their physical characteristics like thickness, folding endurance, water uptake, bioadhesive strength, drug content uniformity, surface pH, Mechanical strength, Scanning electron microscopy (SEM), In-vitro release study, Invitro residence time study and Kinetic study. The results obtained showed no physical-chemical incompatibility between the drug and the polymers. F6 formulation has been selected as the best formulation among all the other formulations. The in-vitro drug diffusion studies from the formulation were found to be sustained release. All the evaluation parameters obtained from the best formulation were found to be satisfactory. The data obtained from the in-vitro release studies were fitted to various kinetic models like zero order, first order, Higuchi model and peppas model. From the kinetic data it was found that drug release follows zero order release kinetics model release by diffusion technique from the polymer. Keywords: Clonidine, HPMCK4M, Xanthan Gum, Guar gum and Mucoadhesive buccal patch.