We have used the REVO weighted ensemble approach followed by Markov state models to identify the ligand unbinding transition states for five ligands unbinding from the enzyme soluble epoxide hydrolase (sEH). This repo provides the counts matrices, properties and state (cluster) labels of the markov state models. The counts matrices can be converted to conformation space networks using CSNAnalysis software (https://github.com/ADicksonLab/CSNAnalysis). The networks are also provided in the gexf formatted files to be visualized in gephi (https://github.com/gephi/gephi).