Advancements in technology have significantly influenced members' lives, like e-health implementation, which brings numerous benefits to the healthcare sector, including cost reduction. However, developing countries are facing challenges in adopting e-health solutions, including electronic health record (EHR) systems. This research conducts a meta-analysis, focusing on the sustainable adoption of e-health in developing countries, using Syria as a case study. The study analyzes 20 peer-reviewed articles collected from online databases. The thematic analysis identifies four interconnected themes: social, economic, cultural, and organizational factors influencing the successful adoption of e-health in developing countries like Syria. Understanding these factors is vital for devising effective strategies to promote the sustainable integration of e-Health technologies in the healthcare systems of developing nations.