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The purpose of the present prospective study, conducted in a tertiary care paediatric unit during June 2013 to October 2014, was to estimate the incidence of reactive thrombocytosis among febrile young infants and assess the utility of platelet count as a potential predictor of serious bacterial infection (SBI). All infants 29 days to 1 year of age, admitted with 0 rectal temperature >38 C were included in the study. Out of the 100 infants studied, 46 had serious bacterial infection. Platelet counts were significantly higher in infants with SBI (60.87%) compared to those without (non SBI), (14%). Majority of infants in SBI group with thrombocytosis had respiratory tract infections (69.57 %, 16/23). Reactive 3 thrombocytosis was a frequent finding in young infants with SBI. Thrombocytosis ≥450,000 cells/mm , in combination with leucocytosis and elevated CRPmay help in early recognition of febrile young infants at risk for SBI