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Hypertrophic obstructive cardiomyopathy (HOCM) is a major potential complication of dexamethasone therapy in preterm infants. HOCM may also be caused by Betamethasone in infants if given for longer time. We present a case of a 3 month old male baby who was prescribed betamethasone by quack for 1 month for treatment of cough and cold. The baby developed HOCM and systolic anterior motion of mitral valve which completely resolved after stoppage of betamethasone in 12 weeks.