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Optical coherence tomography angiography (OCTA) could be a valid tool to detect choroidal neovascularization (CNV) in neovascular age-related macular degeneration (nAMD), allowing the analysis of the type, the morphology, and the extension of CNV in most of the cases. This retrospective cross-sectional study, aimed to highlight the role of optical coherence tomography angiography (OCTA) as compared to fluorescein angiography (FA) in the evaluation of age related macular degeneration (AMD).was conducted at tertiary eye care centre. This study enrolled 24 patients (48 eyes). All patients underwent swept-source optical coherence tomography (SS-OCT), swept-source OCTA, and fundus fluorescein angiography (FFA). OCTA was used to evaluate neovascular networks in terms of their type, location and extent of visualization. Sensitivity and specificity of the method were assessed based on FFA diagnosis as the gold standard. In our study, the sensitivity and specificity of OCTA in detecting CNV secondary to wet AMD seem to be high which were 85.1% and 80% respectively. OCT angiography may be clinically useful to evaluate the CNV activity and response to treatment as well as to differentiate the various types of CNV in wet AMD.