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Bone Marrow Aspiration Study in Pancytopenia: Study for Diagnostic Efficacy from Central India

Authors: Isha; Hazari, Rakesh Singh; Patle, Yogesh;

Bone Marrow Aspiration Study in Pancytopenia: Study for Diagnostic Efficacy from Central India

Abstract

{"references": ["1. Ishtiaq O, Baqai HZ, Anwer F, Hussai N. Patterns of pancytopenia patients in a general medical ward and a proposed diagnostic approach. Connective Tissue. 2007;4(5):5.", "2. Young NS. Aplastic anemia, myelodysplasia, and related bone marrow failure syndromes. Harrisons Principles of Internal Medicine. 2005;16(1):617", "3. Khodke K, Marwah S, Buxi G, Yadav RB, Chaturvedi NK. Bone marrow examination in cases of pancytopenia. J Indian Acad Clin Med. 2001;1(2):1-2", "4. Dasgupta S, Mandal PK, Chakrabarti S. Etiology of Pancytopenia: An observation from a referral medical institution of Eastern Region of India. J Lab Physicians. 2015;7(2):90", "5. Guinan EC, Shimamura A. Acquired and inherited aplastic anemia syndromes. Wintrobes's Clinical Hematology. 2004:1398-419.", "6. Khunger JM, Arulselvi S, Sharma U, Ranga S, Talib VH. Pancytopenia--a clinico haematological study of 200 cases. Indian J Patho Microbiol. 2002;45(3):375- 9.", "7. Tilak V, Jain R. Pancytopenia--a clinico-hematologic analysis of 77 cases. Indian J Patho Microbiol. 1999;42(4):399-404.", "8. Heimpel H. Incidence of Aplastic-Anemia-the Relevance of Diagnostic Criteria. Blood. 1987; 70(6):1718-21.", "9. Varma N, Dash S. A reappraisal of underlying pathology in adult patients presenting with pancytopenia. Tropical and Geographical Medicine. 1992;44(4):322-7.", "10. Hossain MA, Akond AK, Chowdhary MK, Sikder AM, Rashid MA. Pancytopenia-A study of 50 cases. Bang J Pathol. 1992;1:9-12.", "11. Wintrobe MM. Clinical Haematology. 8th (Edn.), Philadelphia: Lea and Febiger 1981; pp 699-915.", "12. Jha A, Sayami G, Adhikari RC, Panta AD, Jha R. Bone Marrow Examinations in cases of Pancytopenia. J Nepal Med Assoc. 2008;47:12-7.", "13. Kumar R, Kalra SP, Kumar H, Anand AC, Madan H. Pancytopenia - a six year study. J Assoc Phys India. 2001;49:1078-81.", "14. Santra G, Das B K. A cross sectional study of the clinical profile and aetiological spectrum of pancytopenia in a tertiary care centre. Singapore Med J. 2010;51(10):806-12", "15. Uniya U, Patle Y, Jain H. Comparative study of bone marrow aspiration and bone marrow clot sections in various haematological disorders. IJRTSAT. 201651(19):17-20.", "16. Pathak R, Jha A, Sayami G. Evaluation of bone marrow in patients with pancytopenia. J Pathol Nepal. 2012;2(4):265-71."]}

Pancytopenia can be caused by a wide variety of etiologies that require evaluation of bone marrow. This is a cross sectional study carried out to identify the various findings in bone marrow aspiration in patients with pancytopenia on peripheral smear examination. Bone marrow aspiration was performed in 103 cases with pancytopenia over a period of 2 years. Bone marrow was hypercellular in 46.6% cases, normocellular in 28.2% cases, inconclusive in 14.5% cases and hypocellular in 10.7% cases. Bone marrow showed megaloblastoid picture in 34% cases, iron deficiency in 9.8% cases, combined iron deficiency and megaloblastoid picture in 8.8% cases, plasmacytosis in 9.8% cases, hypoplastic anemia in 4.9% cases, reactive changes in 2.9% cases, acute leukemia in 1.9% cases, chronic myeloid leukemia chronic phase in 2.9% cases, acute lymphoblastic leukemia in 2.9% cases, idiopathic thrombocytopenic purpura in 1.9% cases and non- hodgkin's lymphoma in 0.9% cases. Study was normal in 3.8% and inconclusive in 15.5% cases. Amongst the total cases 6.8% were below 10 years of age and a total of 46.7% were 30 years and below. Bone marrow aspiration was able to establish diagnosis in 80.7% cases. In conclusion, bone marrow aspiration can diagnose the etiological factors in majority of cases of pancytopenia.

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Keywords

pancytopenia, bone marrow, diagnostic efficacy

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popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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