{"references": ["1. Held M, Laubscher M, Xpert G. Polymerase chain reaction for spinal tuberculosis- an accurate and rapid diagnostic test. Bone Joint J. 2014;96- B:1366\u20139.", "2. Cheng VC, Yam WC, Hung IF, Woo PC, Lau SK, Tang BS, et al. Clinical evaluation of the polymerase chain reaction for the rapid diagnosis of tuberculosis. J Clin Pathol. 2004;57(3):281\u20135 .", "3. Specimen processing of CSF, lymph nodes and other tissues for Xpert MTB/RIF. Available from: https://tbcindia.gov.in/showfile.php?lid=3255 [Accessed 13 Oct 2017].", "4. Shanley DJ. Tuberculosis of the spine: imaging features.Am J Roentgenol. 1995;164(3):659-4.", "5. Garg RK, Somvanshi DS. Spinal tuberculosis: A review. J Spinal Cord Med. 2011;34(5):440-54.", "6. No authors listed. WHO tuberculosis report 2016. http://www.who.int/tb/publications/global_report /en/ [Accessed 18 Oct 2017].", "7. Monni T, Visser A, Visser H, Motsitsi S. Clinical utility of tissue polymerase chain reaction in the diagnosis of spinal tuberculosis. SA Orthop J. 2012;11:23-27.", "8. Gu Y, Wang G, Dong W, et al. Xpert MTB/RIF and GenoType MTBDRplus assays for the rapid diagnosis of bone and joint tuberculosis. Intnat J Infect Dis. 2015;36:27\u201330.", "9. Held M, Laubscher M. Diagnostic accuracy of the Xpert MTB/RIF assay for extrapulmonary Tuberculosis in children with Musculoskeletal Infection. Pediatr Infect Dis J. 2016;35:1165\u20138", "10. Patgaonkar P R, Nagariya SP. Agrawal V, Tuberculosis of spine. J Craniovert Jun Spine. 2010;1(2):74-85.", "11. Turgut M. Spinal tuberculosis (Pott's disease): its clinical presentation,surgical management, and outcome. A survey study on 694 patients. Springer-Verlag. Neurosurg Rev. 2001;24:8-13.", "12. Hsu LC, Cheng CL, Leong JC. Pott's paraplegia of late onset: the cause of compression and results after anterior decompression. J Bone Joint Surg Br. 1988;70(4):534\u20138 .", "13. Cormican L, Hammal R, Messenger J, Milburn HJ. Current difficulties in the diagnosis and management of spinal tuberculosis. Postgrad Med J. 2006;82(963):46-51."]}

Cartridge-Based Nucleic Acid Amplification Testing (CB-NAAT) is a rapid molecular test which is endorsed by Indian RNTCP for the diagnosis of extrapulmonary tuberculosis. However, Indian RNTCP has not specified its use in diagnosis of bone and joint TB. CBNAAT was used to test its accuracy in 42 patients with suspected spinal tuberculosis. Samples taken were split and simultaneously sent for CBNAAT, liquid culture and histopathology. The sensitivity and specificity of CBNAAT against liquid culture was 81.25% and 90.9% respectively. The sensitivity and specificity of CBNAAT against histopathology was 81.25% and 83.3% respectively. Hence, CBNAAT has fairly high sensitivity and specificity in spinal tuberculosis. CBNAAT can be considered as an initial test in the diagnosis of spinal tuberculosis.