This repository contains a multi-scanner, scan-rescan dataset comprising thirty (30) whole-brain 3D MRI acquisitions. Each scan acquisition (n = 30) includes whole-brain quantitative MRI maps (MRF T1, MRF T2, and ADC) and weighted MR images (T1w MPRAGE, T2w SPACE, and T2w FLAIR). Five healthy subjects (deidentified) were scanned over three scanners (all 3T field strength). Each subject was scanned twice per scanner, for a total of 30 scans (5 subjects × 3 scanners × 2 scans). All data was acquired at University Hospitals Cleveland Medical Center and Case Western Reserve University. This dataset was used in the analysis for the following research article published in Investigative Radiology: "Physics-Informed Discretization for Reproducible and Robust Radiomic Feature Extraction Using Quantitative MRI" and request this article be referenced in all research works that use this dataset.