SpecHLA is a software package for full-resolution HLA typing. It is designed to reconstruct entire diploid sequences of HLA genes and can infer loss of heterozygosity (LOH) events. SpecHLA supports various sequencing data protocols, including paired-end reads, 10x linked-reads, Hi-C, PacBio, and ONT (Oxford Nanopore Technologies). It offers the flexibility to incorporate pedigree information and genotype frequency to enhance the accuracy of HLA typing. For more information, please visit the GitHub repository at https://github.com/deepomicslab/SpecHLA.