Rwanda’s private sector and Small and Medium Enterprises (SMEs) in particular, have been facing a lot of defies as many SMEs started and after one or two years collapsed and do not exist anymore. This study utilized descriptive survey research design and multiple linear regressions for testing hypotheses. The population of this study comprise with 273 SMEs in Nyarugenge district. The respondents were the managers of selected SMEs in Nyarugenge District and the researcher used purposive and convenience sampling technique for selecting 73 respondents. The statistical results implies from Null Hypothesis (H0) that Adjusted R square was 0.110, F-test is 3.229 and is significant at .017 therefore it means that all commercial bank activities variables jointly have positive and significant effect on business expansion in selected SMEs in Nyarugenge District.